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The recommended dose for ritonavir-treated patients is 25 mg prior to sexual activity and the recommended maximum dose is 25 mg within a 48 hour period because concomitant administration increased the blood levels of sildenafil by 11-fold [ see Warnings and Precautions () , Drug Interactions () , and Clinical Pharmacology () ].
Sildenafil citrate is a white to off-white crystalline powder with a solubility of mg/mL in water and a molecular weight of .