Amlodipine was first patented in 1986 with commercial sale beginning in 1990.  It is on the World Health Organization's List of Essential Medicines , the most effective and safe medicines needed in a health system .  It is available as a generic medication .  Wholesale cost in the developing world is US$ to per day for a typical dose as of 2015.  In the United States, a month's supply costs less than $25.